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左云

左云,博士,讲师,硕士生导师。2022年7月获厦门大学计算机科学与技术专业工学博士学位。2023年1月入职于江南大学人工智能与计算机学院。

招生信息

1、学术型研究生招生:计算机科学与技术、软件工程、人工智能。

2、专业型研究生招生:计算机技术、软件工程、人工智能。

联系方式

zuoyun@jiangnan.edu.cn

研究方向

理论研究:

(1)面向生物序列的大语言模型适配理论研究;(2)不平衡生物数据的智能体集成分类与降维理论研究;(3)生物序列智能聚类与去冗余的智能体机制研究;

应用研究:

(1)生物序列分类大模型工具开发;(2)疾病关联预测智能体系统构建;(3)病毒生物信息学智能分析平台研发;(4)面向行业的智能软件和系统开发;(5)行业大模型开发与应用。

人才培养

(1)研究生:作为指导老师指导9名研究生,2人获国家奖学金,1人获江苏省研究生科研与实践创新计划项目,2人分别获省、市级三好学生荣誉称号,1人获校优毕设。本科生:指导本科生发表SCI检索论文6篇;

(2)本科生毕设:指导本科生毕设共20篇,其中获校优毕设7篇、省级优秀毕设1篇;获2025年江南大学本科优秀毕业论文指导教师。

(3)入职以来,以第一指导老师指导A类竞赛国赛一等奖1项、二等奖4项;

(4)以第一指导老师指导国家级大创2项、省级大创1项,已全部以优秀结项。

科学研究

(1)国家自然科学基金青年科学基金1项(主持);江苏省科技计划项目青年基金项目1项(主持);横向(技术服务)1项(主持);

(2)截止到2026年9月,在Briefings in Bioinformatics、PLOS Computational Biology、Journal of Chemical Information and Modeling、IEEE Journal of Biomedical and Health Informatics、Bioinformatics等国际知名生信期刊上发表SCI论文三十余篇;

科研成果(论文、论著、专利)

论文:

(1) ProCAS: Multi-Lysine Post-Translational Modification Site Prediction Based on the SPUS Algorithm and the ProCAS Architecture,MOLECULAR & CELLULAR PROTEOMICS, 2026.

(2) MEGH-DDI: MolT5-Driven Edge-Aware Graph Learning with Hop2Token Representation for Drug–Drug Interaction Prediction,PLOS Computational Biology, 2026.

(3) Important Progress in Antimicrobial Peptide Prediction Research in the Past Five Years,ANALYTICAL BIOCHEMISTRY, 2026.

(4) ISUMsite: Identification of sumoylation sites based on Smote-ENN resampling technique,ANALYTICAL BIOCHEMISTRY, 2026.

(5) MVFAN-Kcr: A Multi-View Feature Fusion and Attention-Based Network for Lysine Crotonylation Site Identification,Interdisciplinary Sciences Computational Life Sciences, 2026.

(6) EnsemGlyPred: Intelligent Prediction System for Lysine Glycation Sites Integrating Deep Semantic Features and Sequence Information, ANALYTICAL BIOCHEMISTRY, 2026.

(7) Yun Zuo*, Chenyi Zhang, Ge Hua, Qiao Ning, Xiangrong Liu, Xiangxiang Zeng, Zhaohong Deng. FKSUDDAPre: A Drug–Disease Association Prediction Framework Based on F-TEST Feature Selection and AMDKSU Resampling with Interpretability Analysis,PLOS Computational Biology, 2026.

(8) XRepDDA: An Interpretable Drug-Disease Association Prediction Framework Leveraging Pretrained Chemical Language Models,Journal of Chemical Information and Modeling, 2026.

(9) ProtFPreDTI: Drug-Target Interaction Prediction Study and LIME Interpretability Analysis Based on ProtBERT Deep Language Model with Adaptive Fuzzy Sampling Strategy,BIOCONJUGATE CHEMISTRY,2026.

(10) EMMPREDMLsub: Multi-label Prediction of mRNA Subcellular Localization Based on the ESM2 Large Language Model and MMDO-MDPU Resampling Strategy, JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS. 2025.

(11)LM-TLIPs: Integrating Large Model and Transfer Learning Technology for Precise Identification of Phosphorylation Sites in SARS-CoV-2.IEEE Journal of Biomedical and Health Informatics,2025.

(12) MlyPredCSED: Based on Extreme Point Deviation Compensated Clustering combined with Cross-Scale Convolutional Neural Networks to predict multiple lysine sites in human. Briefings in Bioinformatics, 2025.

(13) MBSCLoc: Multi-label subcellular localization predict based on cluster balanced subspace partitioning method and multi-class contrastive representation learning.IEEE Journal of Biomedical and Health Informatics,2025.

(14) EnsembleSE: identification of super-enhancers basedon ensemble learning. Briefings in Functional Genomics, 2025, 24, elaf003.

(15) Research progress on Drug-Target Interactions in the last five years. Analytical Biochemistry 2024, 697:115691.

(16) MuSE: A deep learning model based on multi-feature fusion forsuper-enhancer prediction. Computational Biology & Chemistry, 2024, 113(000).

(17) PreMLS: The undersampling technique basedon ClusterCentroids to predict multiple lysinesites. PLOS Computational Biology, 2024, 20(10).

(18) NBCR-ac4C: A Deep Learning Framework Based on MultivariateBERT for Human mRNA N4-Acetylcytidine Sites Prediction.Journal of Chemical Information and Modeling, 2024, 64(20):8.

(19) MSlocPRED: deep transfer learning-based identificationof multi-label mRNA subcellular localization.Briefings in Bioinformatics, 2024, bbae504.

(20) ILYCROsite: Identiffcation of lysine crotonylation sites based on FCM-GRNN undersampling technique.Computational Biology and Chemistry,2024,113:108212.

(21) Glypred: Lysine Glycation Site Prediction viaCCU−LightGBM−BiLSTM Framework with Multi-Head AttentionMechanism. Journal of Chemical Information and Modeling,2024,64(16):6699-6711.

(22) Research progress on prediction of RNA-protein binding sites in the past five years. Analytical Biochemistry, 691 (2024) , 115535.

(23) MINDG: a drug–target interaction prediction method basedon an integrated learning algorithm. Bioinformatics, 2024, 40(4), btae147.

(24)CarSitePred: anintegrated algorithm for identifying carbonylated sites based on KNDUALNDOT resampling technique.Journal of Biomolecular Structure and Dynamics, 2024.

(25) MLNGCF: circRNA–disease associations prediction withmultilayer attention neural graph-based collaborativefiltering. Bioinformatics, 2023.

(26) MLysPRED: Graph-based multi-view clustering and multi-dimensional normal distribution resampling techniques to predict multiple lysine sites. Briefings in Bioinformatics, 2022, 23(5): bbac277.

(27) CarSite-II: an integrated classification algorithm for identifying carbonylated sites based on K-means similarity-based undersampling and synthetic minority oversampling techniques. BMC Bioinformatics, 2021, 22(1).

(28) Pm6A: an Integrated Classification Algorithm for identifying m6A Sites. IEEE BIBM 2021, 235-240.

(29) 2lpiRNApred: A two-layered integrated algorithm for identifying piRNAs and their functions based on LFE-GM feature selection. RNA Biology, 2020,17(6): 892-902.

(30) A deep neural network for antimicrobial peptide recognition. IEEE BIBM 2019, 2019:82-85.

(31) Identification of Cancerlectins by Split Bi-profile Bayes Feature Extraction. Current Proteomics, 2018, 15(3).

(32) O-GlcNAcPRED-II: an integrated classification algorithm for identifying O-GlcNAcylation sites based on fuzzy undersampling and K-means PCA oversampling technique. Bioinformatics, 2018, 34(12): 2029-2036.

(33) S-SulfPred: A sensitive predictor to capture S-sulfenylation sites based on resampling one-sided selection undersampling-synthetic minority oversampling technique. Journal of Theoretical Biology, 422:84-89.

(34) Computional prediction of protein O-GlcNAc modification, Methods in molecular biology (Clifton, N.J.), 2018. (COMPUTATIONAL SYSTEMS BIOLOGY: METHODS AND PROTOCOLS,丛书: Methods in Molecular Biology,卷: 1754页: 235-246,出版年: 2018).

(35) CarSite: identify carbonylated sites of human proteins based on a one-sided selection resampling method. Molecular BioSystems, 2017, 13(11): 2362-2369.

专利:

(1)基于EPDCC技术识别多种赖氨酸修饰位点的方法,专利号:ZL 2024 1 1550944.6(已授权)

(2)基于LLM和RBMO的DTI预测方法,专利号:ZL 2025 1 1976691.3(已授权)

(3)基于多种分类算法集成学习的智能医疗欺诈监测方法,申请号:2024105857823

(4)基于深度迁移学习的多标签亚细胞定位预测方法,申请号:2024107520072

(5)基于ClusterCentroids欠采样技术预测多种赖氨酸修饰位点的方法,申请号:2024108533879

(6)基于平衡子空间和对比学习的多标签亚细胞定位方法,申请号:2024111421987

(7)基于大模型技术识别磷酸化修饰位点的方法,申请号:2024116964759

(8)基于实体知识驱动的语言模型对琥珀酰化位点的识别方法,申请号:2026100964955

技术支持:信息化建设管理处

校内备案号:JW备170019

地址:江苏省无锡市蠡湖大道1800号

邮编:214122

联系电话:0510-85327307

服务邮箱:rgznxy@jiangnan.edu.cn

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